The main study into the effectiveness of semaglutide (Ozempic) was 72 weeks duration. In practice, most pts plateau after about 60 weeks. It's licensed for use for a maximum of 2 years, after which about 98% of patients regain at least two-thirds of the weight they have lost within a year (see link below if you're interested). Even worse, all the cardiometabolic benefits which accompany the weight loss - lower BP, better glucose control and insulin secretion/response, lower LDL cholesterol etc - are entirely reversed once stopping semaglutide. In practice, the overwhelming majority of patients regain
all the weight that they had lost, for entirely predictable reasons.
I'd said in a previous post that the acid test as to whether or not she's taking a drug like ozempic (not that it's anyone's business but hers) is if she manages to keep the weight off for about 18-24 months. She's a classic yo-yo dieter, and in previous cycles, she's lost and regained a couple of stone in a 6-9 month period (again, a very classic pattern). If she suddenly loses a lot of weight
and manages to keep it off, then you can be pretty sure that something has changed this time...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542252/